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CDC25A (S124) Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P30304 |
| Other Accession | P48965 |
| Reactivity | Human |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59087 Da |
| Gene ID | 993 |
|---|---|
| Other Names | M-phase inducer phosphatase 1, 3.1.3.48, Dual specificity phosphatase Cdc25A, CDC25A |
| Target/Specificity | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human. |
| Dilution | WB~~1:2000 IHC-P~~1:100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDC25A (S124) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDC25A |
|---|---|
| Function | Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
References
Galaktionov K.I.,et al.Cell 67:1181-1194(1991).
Varmeh-Ziaie S.,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Wegener S.,et al.Eur. J. Cell Biol. 79:810-815(2000).
Falck J.,et al.Nature 410:842-847(2001).
Donzelli M.,et al.EMBO J. 21:4875-4884(2002).
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