IFT57 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NWB7 |
Other Accession | Q5EA95 |
Reactivity | Human |
Predicted | Bovine |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 49108 Da |
Gene ID | 55081 |
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Other Names | Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI |
Target/Specificity | This IFT57 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 159-193 amino acids from the Central region of human IFT57. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | IFT57 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IFT57 |
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Synonyms | DERP8, ESRRBL1, HIPPI |
Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'- AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
Cellular Location | Cell projection, cilium {ECO:0000250|UniProtKB:Q8BXG3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5EA95}. Note=Concentrates within the inner segment of cilia. |
Tissue Location | Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level) |
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Background
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
References
Gervais F.G.,et al.Nat. Cell Biol. 4:95-105(2002).
Pasutto F.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ikeda A.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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