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THBD Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IF, E |
|---|---|
| Primary Accession | P07204 |
| Other Accession | Q71U07 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60329 Da |
| Gene ID | 7056 |
|---|---|
| Other Names | Thrombomodulin, TM, Fetomodulin, CD141, THBD, THRM |
| Target/Specificity | This THBD antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 92-126 amino acids from human THBD. |
| Dilution | IF~~1:25 WB~~1:2000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | THBD Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THBD |
|---|---|
| Synonyms | THRM |
| Function | Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis (PubMed:10761923). Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway (PubMed:29323190, PubMed:33836597, PubMed:9395524). Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition (PubMed:26663133). Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation (By similarity). Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response (PubMed:15841214). |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Endothelial cells are unique in synthesizing thrombomodulin |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
References
Suzuki K.,et al.EMBO J. 6:1891-1897(1987).
Wen D.,et al.Biochemistry 26:4350-4357(1987).
Jackman R.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6425-6429(1987).
Shirai T.,et al.J. Biochem. 103:281-285(1988).
Deloukas P.,et al.Nature 414:865-871(2001).
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