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CD24 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P25063 |
| Other Accession | Q6SW14 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 8083 Da |
| Gene ID | 100133941 |
|---|---|
| Other Names | Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A |
| Target/Specificity | This CD24 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 17-38 amino acids from the Central region of human CD24. |
| Dilution | WB~~1:1000-1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD24 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD24 |
|---|---|
| Synonyms | CD24A |
| Function | May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin- like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Location | B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. |
Provided below are standard protocols that you may find useful for product applications.
Background
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
References
Kay R.,et al.J. Immunol. 147:1412-1416(1991).
Jackson D.,et al.Cancer Res. 52:5264-5270(1992).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Hough M.R.,et al.Genomics 22:154-161(1994).
Zarn J.A.,et al.Biochem. Biophys. Res. Commun. 225:384-391(1996).
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