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SULF1 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q8IWU6 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101027 Da |
| Gene ID | 23213 |
|---|---|
| Other Names | Extracellular sulfatase Sulf-1, hSulf-1, 3.1.6.-, SULF1, KIAA1077 |
| Target/Specificity | This SULF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 704-738 amino acids from human SULF1. |
| Dilution | WB~~1:2000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SULF1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SULF1 |
|---|---|
| Synonyms | KIAA1077 |
| Function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563). |
| Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8VI60}. Cell surface |
| Tissue Location | Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down- regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
References
Morimoto-Tomita M.,et al.J. Biol. Chem. 277:49175-49185(2002).
Lai J.,et al.J. Biol. Chem. 278:23107-23117(2003).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).
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