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PLCB3 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q01970 |
| Other Accession | P51432, Q99JE6 |
| Reactivity | Mouse, Rat |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 138799 Da |
| Gene ID | 5331 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3, 3.1.4.11, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3, PLCB3 |
| Target/Specificity | This PLCB3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 16-50 amino acids from human PLCB3. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLCB3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLCB3 {ECO:0000303|PubMed:20966218, ECO:0000312|EMBL:AAA77683.1} |
|---|---|
| Function | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). |
| Cellular Location | Cytoplasm. Membrane {ECO:0000250|UniProtKB:Q99JE6}. Nucleus {ECO:0000250|UniProtKB:P51432} Note=And particulate fractions. {ECO:0000250|UniProtKB:Q99JE6} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
References
Mazuruk K.,et al.Biochem. Biophys. Res. Commun. 212:190-195(1995).
Lagercrantz J.,et al.Genomics 26:467-472(1995).
Taylor T.D.,et al.Nature 440:497-500(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Carozzi A.J.,et al.Eur. J. Biochem. 210:521-529(1992).
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