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Transferrin Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P02787 |
| Other Accession | A5A6I6 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77050 Da |
| Gene ID | 7018 |
|---|---|
| Other Names | Serotransferrin, Transferrin, Beta-1 metal-binding globulin, Siderophilin, TF |
| Target/Specificity | This Transferrin antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 432-466 amino acids from human Transferrin. |
| Dilution | WB~~1:2000 IHC-P~~1:25 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Transferrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TF (HGNC:11740) |
|---|---|
| Function | Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed by the liver and secreted in plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
References
Yang F.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:2752-2756(1984).
Schaeffer E.,et al.Gene 56:109-116(1987).
Hershberger C.L.,et al.Ann. N. Y. Acad. Sci. 646:140-154(1991).
Beutler E.,et al.Blood 96:4071-4074(2000).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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