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ST3GAL4 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q11206 |
| Other Accession | P61130 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38045 Da |
| Gene ID | 6484 |
|---|---|
| Other Names | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase 4, Alpha 2, 3-ST 4, Beta-galactoside alpha-2, 3-sialyltransferase 4, 2.4.99.-, Alpha 2, 3-sialyltransferase IV, Gal-NAc6S, Gal-beta-1, 4-GalNAc-alpha-2, 3-sialyltransferase, SAT-3, ST-4, ST3Gal IV, ST3GalIV, ST3GalA.2, STZ, Sialyltransferase 4C, SIAT4-C, ST3GAL4, CGS23, NANTA3, SIAT4C, STZ |
| Target/Specificity | This ST3GAL4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 26-57 amino acids from human ST3GAL4. |
| Dilution | WB~~1:1000-1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ST3GAL4 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST3GAL4 |
|---|---|
| Synonyms | CGS23, NANTA3, SIAT4C, STZ |
| Function | A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500). Catalyzes the transfer of sialic acid (N-acetyl- neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc- terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E- selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin- mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500). |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid |
| Tissue Location | Highly expressed in adult placenta, heart and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative.
References
Kitagawa H.,et al.J. Biol. Chem. 271:931-938(1996).
Kitagawa H.,et al.J. Biol. Chem. 269:1394-1401(1994).
Sasaki K.,et al.J. Biol. Chem. 268:22782-22787(1993).
Grahn A.,et al.Glycoconj. J. 18:759-767(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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