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TTN Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IHC-P - TTN Antibody (N-term) AP21985a
    Immunohistochemical analysis of TITIN in Human skeletal muscle tissue sections(IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde at room temperature; antigen retrieval was by heat mediation with a EDTA buffer (pH9. 0). Samples were incubated with primary antibody (1:500) for 1 hours at room temperature. A undiluted biotinylated CRF Anti-Polyvalent HRP Polymer antibody was used as the secondary antibody.
    detail
  • IHC-P - TTN Antibody (N-term) AP21985a
    Immunohistochemical analysis of TITIN in Human heart tissue sections(IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde at room temperature; antigen retrieval was by heat mediation with a EDTA buffer (pH9. 0). Samples were incubated with primary antibody (1:500) for 1 hours at room temperature. A undiluted biotinylated CRF Anti-Polyvalent HRP Polymer antibody was used as the secondary antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q8WZ42
Other Accession A2ASS6
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 3816030 Da
Additional Information
Gene ID 7273
Other Names Titin, 2.7.11.1, Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14, TTN
Target/Specificity This TTN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 7169-7203 amino acids from the N-terminal region of human TTN.
Dilution IHC-P~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTTN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTN
Function Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
Cellular Location Cytoplasm. Nucleus
Tissue Location Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level)
Research Areas
Citations (0)
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Background

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

References

Labeit S.,et al.Science 270:293-296(1995).
Freiburg A.,et al.Circ. Res. 86:1114-1121(2000).
Bang M.-L.,et al.Circ. Res. 89:1065-1072(2001).
Hillier L.W.,et al.Nature 434:724-731(2005).
Gautel M.,et al.J. Cell Sci. 109:2747-2754(1996).

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$ 365.00
$ 140.00
Cat# AP21985a
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