VLDLR Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, E |
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Primary Accession | P98155 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 96098 Da |
Antigen Region | 608-642 aa |
Gene ID | 7436 |
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Other Names | Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR |
Target/Specificity | This VLDLR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 608-642 amino acids from human VLDLR. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | VLDLR Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | VLDLR |
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Function | Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE- containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity). |
Cellular Location | Cell membrane; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein |
Tissue Location | Abundant in heart and skeletal muscle; also ovary and kidney; not in liver |

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Provided below are standard protocols that you may find useful for product applications.
Background
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
References
Gafvels M.E.,et al.Somat. Cell Mol. Genet. 19:557-569(1993).
Webb J.C.,et al.Hum. Mol. Genet. 3:531-537(1994).
Sakai J.,et al.J. Biol. Chem. 269:2173-2182(1994).
Oka K.,et al.Genomics 20:298-300(1994).
Humphray S.J.,et al.Nature 429:369-374(2004).

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