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UGT2B4 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P06133 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60513 Da |
| Gene ID | 7363 |
|---|---|
| Other Names | UDP-glucuronosyltransferase 2B4, UDPGT 2B4, HLUG25, Hyodeoxycholic acid-specific UDPGT, UDPGTh-1, UGT2B4, UGT2B11 |
| Target/Specificity | This UGT2B4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 338-370 amino acids from the Central region of human UGT2B4. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UGT2B4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UGT2B4 (HGNC:12553) |
|---|---|
| Synonyms | UGT2B11 |
| Function | UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
References
Jackson M.R.,et al.Biochem. J. 242:581-588(1987).
Jin C.-J.,et al.Biochem. Biophys. Res. Commun. 194:496-503(1993).
Levesque E.,et al.Pharmacogenetics 9:207-216(1999).
McKenzie P.I.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Riedy M.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
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