ADAMTS15 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8TE58 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 103287 Da |
Antigen Region | 29-59 aa |
Gene ID | 170689 |
---|---|
Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 15, ADAM-TS 15, ADAM-TS15, ADAMTS-15, 3424-, ADAMTS15 |
Target/Specificity | This ADAMTS15 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the region of human ADAMTS15. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ADAMTS15 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ADAMTS15 |
---|---|
Function | Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. |
Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P59384}. Cell surface {ECO:0000250|UniProtKB:P59384} |
Tissue Location | Expressed in fetal liver and kidney, but not in any of the adult tissues examined. |
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Provided below are standard protocols that you may find useful for product applications.
References
Cal S.,et al.Gene 283:49-62(2002).
Sjoeblom T.,et al.Science 314:268-274(2006).
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