PNMT Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P11086 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 30855 Da |
Gene ID | 5409 |
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Other Names | Phenylethanolamine N-methyltransferase, PNMTase, Noradrenaline N-methyltransferase, PNMT, PENT |
Target/Specificity | This PNMT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 158-192 amino acids from the Central region of human PNMT. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PNMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNMT |
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Synonyms | PENT |
Function | Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L- methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617, PubMed:16363801, PubMed:8812853). Also methylates normetanephrine (By similarity). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Converts noradrenaline to adrenaline.
References
Kaneda N.,et al.J. Biol. Chem. 263:7672-7677(1988).
Sasaoka T.,et al.Neurochem. Int. 15:555-565(1989).
Baetge E.E.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3648-3652(1988).
Martin J.L.,et al.Structure 9:977-985(2001).
Gee C.L.,et al.Biochemistry 44:16875-16885(2005).
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