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CLEC16A Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q2KHT3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 117715 Da |
| Gene ID | 23274 |
|---|---|
| Other Names | Protein CLEC16A, C-type lectin domain family 16 member A {ECO:0000312|HGNC:HGNC:29013}, CLEC16A (HGNC:29013), KIAA0350 |
| Target/Specificity | This CLEC16A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 773-805 amino acids from the C-terminal region of human CLEC16A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLEC16A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLEC16A (HGNC:29013) |
|---|---|
| Synonyms | KIAA0350 |
| Function | Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Lysosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Note=Associates with the endolysosome membrane. {ECO:0000250|UniProtKB:Q80U30} |
| Tissue Location | Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells |
Provided below are standard protocols that you may find useful for product applications.
Background
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
References
Nagase T.,et al.DNA Res. 4:141-150(1997).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hakonarson H.,et al.Nature 448:591-594(2007).
Soleimanpour S.A.,et al.Cell 157:1577-1590(2014).
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