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(Mouse) Ihh Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P97812 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45485 Da |
| Gene ID | 16147 |
|---|---|
| Other Names | Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, Ihh |
| Target/Specificity | This mouse Ihh antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 57-90 amino acids from the N-terminal region of mouse Ihh. |
| Dilution | WB~~1:2000 IHC-P~~1:25 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Ihh Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ihh {ECO:0000312|MGI:MGI:96533} |
|---|---|
| Function | [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C- terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling. Associated with the very-low- density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (By similarity). |
| Cellular Location | [Indian hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q14623}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465} |
| Tissue Location | In the adult kidney, found in proximal convoluted and proximal straight tubule. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
References
Valentini R.P.,et al.J. Biol. Chem. 272:8466-8473(1997).
Echelard Y.,et al.Cell 75:1417-1430(1993).
St Jacques B.,et al.Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
Chang D.T.,et al.Development 120:3339-3353(1994).
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