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ASGR2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P07307 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35092 Da |
| Gene ID | 433 |
|---|---|
| Other Names | Asialoglycoprotein receptor 2, ASGP-R 2, ASGPR 2, C-type lectin domain family 4 member H2, Hepatic lectin H2, HL-2, ASGR2, CLEC4H2 |
| Target/Specificity | This ASGR2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-54 amino acids from the N-terminal region of human ASGR2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASGR2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASGR2 |
|---|---|
| Synonyms | CLEC4H2 |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| Cellular Location | Membrane; Single-pass type II membrane protein. |
| Tissue Location | Expressed exclusively in hepatic parenchymal cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
References
Spiess M.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6465-6469(1985).
Paietta E.,et al.Hepatology 15:395-402(1992).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Pan H.,et al.Genomics 77:58-64(2001).
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