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TSHR Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P16473 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86844 Da |
| Gene ID | 7253 |
|---|---|
| Other Names | Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3 |
| Target/Specificity | This TSHR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 217-252 amino acids from the Central region of human TSHR. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSHR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSHR |
|---|---|
| Synonyms | LGR3 |
| Function | Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
References
Nagayama Y.,et al.Biochem. Biophys. Res. Commun. 165:1184-1190(1989).
Libert F.,et al.Biochem. Biophys. Res. Commun. 165:1250-1255(1989).
Misrahi M.,et al.Biochem. Biophys. Res. Commun. 166:394-403(1990).
Frazier A.L.,et al.Mol. Endocrinol. 4:1264-1276(1990).
Graves P.N.,et al.Biochem. Biophys. Res. Commun. 187:1135-1143(1992).
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