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Mouse Nr5a2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P45448 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64020 Da |
| Antigen Region | 200-233 aa |
| Gene ID | 26424 |
|---|---|
| Other Names | Nuclear receptor subfamily 5 group A member 2, Liver receptor homolog 1, LRH-1, Nr5a2, Lrh1 |
| Target/Specificity | This Mouse Nr5a2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 200-233 amino acids from the Central region of Mouse Nr5a2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Nr5a2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nr5a2 |
|---|---|
| Synonyms | Lrh1 |
| Function | Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:O00482}. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Binds to promoters containing the sequence element 5'- AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).
References
Tugwood J.D.,et al.Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
Sablin E.P.,et al.Mol. Cell 11:1575-1585(2003).
Li Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:9505-9510(2005).
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$ 365.00
$ 140.00
Cat# AP21181c
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