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LMCD1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NZU5 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40833 Da |
| Antigen Region | 316-350 aa |
| Gene ID | 29995 |
|---|---|
| Other Names | LIM and cysteine-rich domains protein 1, Dyxin, LMCD1 |
| Target/Specificity | This LMCD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 316-350 amino acids from the C-terminal region of human LMCD1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LMCD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LMCD1 |
|---|---|
| Function | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6- mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. |
| Cellular Location | Cytoplasm. Nucleus. Note=May shuttle between the cytoplasm and the nucleus. |
| Tissue Location | Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
References
Bespalova I.N.,et al.Genomics 63:69-74(2000).
Holt H.H.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Rath N.,et al.Mol. Cell. Biol. 25:8864-8873(2005).
Bian Z.Y.,et al.Hypertension 55:257-263(2010).
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