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ABCA2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BZC7 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 269833 Da |
| Antigen Region | 1339-1373 aa |
| Gene ID | 20 |
|---|---|
| Other Names | ATP-binding cassette sub-family A member 2, ATP-binding cassette transporter 2, ATP-binding cassette 2, ABCA2, ABC2, KIAA1062 |
| Target/Specificity | This ABCA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1339-1373 amino acids from the Central region of human ABCA2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ABCA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCA2 (HGNC:32) |
|---|---|
| Synonyms | ABC2, KIAA1062 |
| Function | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). |
| Cellular Location | Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Forms discrete, punctate intracellular vesicles. |
| Tissue Location | [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.
References
Kaminski W.E.,et al.Biochem. Biophys. Res. Commun. 281:249-258(2001).
Vulevic B.,et al.Cancer Res. 61:3339-3347(2001).
Humphray S.J.,et al.Nature 429:369-374(2004).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
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