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FAM168B Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FAM168B Antibody (C-term) AP21018c
    Western blot analysis of lysate from mouse brain tissue lysate, using FAM168B Antibody (C-term)(Cat. #AP21018c). AP21018c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession A1KXE4
Other Accession D4AEP3, Q80XQ8, A8E639
Reactivity Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20324 Da
Antigen Region 165-199 aa
Additional Information
Gene ID 130074
Other Names Myelin-associated neurite-outgrowth inhibitor, Mani, p20, FAM168B, KIAA0280L, MANI
Target/Specificity This FAM168B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 165-199 amino acids from the C-terminal region of human FAM168B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFAM168B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FAM168B
Synonyms KIAA0280L, MANI
Function Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Cellular Location Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane {ECO:0000250|UniProtKB:Q80XQ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80XQ8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80XQ8}. Note=Expressed in neuronal cell bodies and axonal fibers. {ECO:0000250|UniProtKB:Q80XQ8}
Tissue Location Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level)
Citations (0)
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Background

Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity).

References

Mishra M.,et al.J. Cell. Mol. Med. 15:1713-1725(2011).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Mishra M.,et al.FEBS Lett. 586:3018-3023(2012).

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$ 365.00
$ 140.00
Cat# AP21018c
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