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(Mouse) Wdr5 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P61965 |
| Other Accession | Q498M4, P61964 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36588 Da |
| Gene ID | 140858 |
|---|---|
| Other Names | WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WD repeat-containing protein BIG-3, Wdr5, Big, Big3 |
| Target/Specificity | This Mouse Wdr5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the region of mouse Wdr5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Wdr5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Wdr5 |
|---|---|
| Synonyms | Big, Big3 |
| Function | Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (PubMed:11551928). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in liver (at protein level). Detected in brain, testis and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
References
Gori F.,et al.J. Biol. Chem. 276:46515-46522(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Jiang H.,et al.Cell 144:513-525(2011).
Yang Y.J.,et al.Cell 151:1097-1112(2012).
Diao Y.,et al.Cell Stem Cell 11:231-241(2012).
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