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EPOR Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P19235 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55065 Da |
| Gene ID | 2057 |
|---|---|
| Other Names | Erythropoietin receptor, EPO-R, EPOR |
| Target/Specificity | This EPOR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 470-504 amino acids from the C-terminal region of human EPOR. |
| Dilution | WB~~1:2000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EPOR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPOR {ECO:0000303|PubMed:2163695, ECO:0000312|HGNC:HGNC:3416} |
|---|---|
| Function | Receptor for erythropoietin, which mediates erythropoietin- induced erythroblast proliferation and differentiation (PubMed:10388848, PubMed:2163695, PubMed:2163696, PubMed:8662939, PubMed:9774108). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (PubMed:11756159). May also activate the LYN tyrosine kinase (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P14753}; Single-pass type I membrane protein |
| Tissue Location | Erythroid cells and erythroid progenitor cells. [Isoform EPOR-S]: Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
References
Winkelmann J.C.,et al.Blood 76:24-30(1990).
Jones S.S.,et al.Blood 76:31-35(1990).
Noguchi C.T.,et al.Blood 78:2548-2556(1991).
Ehrenman K.,et al.Exp. Hematol. 19:973-977(1991).
Nakamura Y.,et al.Science 257:1138-1141(1992).
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