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Mouse Hes1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P35428 |
| Other Accession | Q04666, Q14469, Q3ZBG4, Q8AVU4, Q6IRB2 |
| Reactivity | Mouse |
| Predicted | Xenopus, Bovine, Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29749 Da |
| Gene ID | 15205 |
|---|---|
| Other Names | Transcription factor HES-1, Hairy and enhancer of split 1, Hes1, Hes-1 |
| Target/Specificity | This Mouse Hes1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 102-137 amino acids from the Central region of Mouse Hes1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Hes1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Hes1 |
|---|---|
| Synonyms | Hes-1 |
| Function | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
References
Takebayashi K.,et al.J. Biol. Chem. 269:5150-5156(1994).
Grbavec D.,et al.Eur. J. Biochem. 258:339-349(1998).
Bae S.-K.,et al.Development 127:2933-2943(2000).
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