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RIOK3 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - RIOK3 Antibody  (Center) AP20884a
    Western blot analysis of lysates from Hela, HepG2, K562 cell line (from left to right), using RIOK3 Antibody (Center)(Cat. #AP20884a). AP20884a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O14730
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 59093 Da
Additional Information
Gene ID 8780
Other Names Serine/threonine-protein kinase RIO3, RIO kinase 3, sudD homolog, RIOK3, SUDD
Target/Specificity This RIOK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 146-179 amino acids from the Central region of human RIOK3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRIOK3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RIOK3
Synonyms SUDD
Function Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).
Cellular Location Cytoplasm.
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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References

Anaya P.,et al.Gene 211:323-329(1998).
Nusbaum C.,et al.Nature 437:551-555(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Greenman C.,et al.Nature 446:153-158(2007).

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$ 365.00
$ 140.00
Cat# AP20884a
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