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(Mouse) Srf Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - (Mouse) Srf Antibody (C-term) AP20866c
    Western blot analysis of lysates from mouse NIH/3T3;rat C6 cell line (from left to right), using Srf Antibody (C-term)(Cat. #AP20866c). AP20866c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9JM73
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 51247 Da
Additional Information
Gene ID 20807
Other Names Serum response factor, SRF, Srf
Target/Specificity This (Mouse) Srf antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 489-524 amino acids from the C-terminal region of human (Mouse) Srf.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Srf Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Srf
Function SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). Required for cardiac differentiation and maturation (PubMed:15169892).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19350017}
Research Areas
Citations (0)
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Background

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (By similarity). Required for cardiac differentiation and maturation.

References

Miwa T.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Zhang X.,et al.J. Biol. Chem. 279:55626-55632(2004).
Parlakian A.,et al.Mol. Cell. Biol. 24:5281-5289(2004).
Zhang X.,et al.Biochem. Biophys. Res. Commun. 346:794-801(2006).
Villen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).

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$ 365.00
$ 140.00
Cat# AP20866c
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