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HIST1H2BM Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99879 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 13989 Da |
| Antigen Region | 10-44 aa |
| Gene ID | 8342 |
|---|---|
| Other Names | Histone H2B type 1-M, Histone H2Be, H2B/e, HIST1H2BM, H2BFE |
| Target/Specificity | This HIST1H2BM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 10-44 amino acids from the N-terminal region of human HIST1H2BM. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HIST1H2BM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | H2BC14 (HGNC:4750) |
|---|---|
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Cellular Location | Nucleus. Chromosome. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
References
Albig W.,et al.Hum. Genet. 101:284-294(1997).
Marzluff W.F.,et al.Genomics 80:487-498(2002).
Mungall A.J.,et al.Nature 425:805-811(2003).
Lubec G.,et al.Submitted (MAR-2007) to UniProtKB.
Cheung W.L.,et al.Cell 113:507-517(2003).
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