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REG3A Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q06141 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19395 Da |
| Gene ID | 5068 |
|---|---|
| Other Names | Regenerating islet-derived protein 3-alpha, REG-3-alpha, Hepatointestinal pancreatic protein, HIP/PAP, Human proislet peptide, Pancreatitis-associated protein 1, Regenerating islet-derived protein III-alpha, Reg III-alpha, Regenerating islet-derived protein 3-alpha 165 kDa form, Regenerating islet-derived protein 3-alpha 15 kDa form, REG3A, HIP, PAP, PAP1 |
| Target/Specificity | This REG3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 105-139 amino acids from the Central region of human REG3A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | REG3A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | REG3A (HGNC:8601) |
|---|---|
| Function | [Regenerating islet-derived protein 3-alpha 15 kDa form]: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan (PubMed:16931762). Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore (PubMed:24256734). |
| Cellular Location | Secreted. Note=Found in the apical region of pancreatic acinar cells |
| Tissue Location | Expressed by keratinocytes (PubMed:27830702). Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level) (PubMed:22727489). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis (PubMed:1469087). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
References
Itoh T.,et al.Biochim. Biophys. Acta 1172:184-186(1993).
Orelle B.,et al.J. Clin. Invest. 90:2284-2291(1992).
Lasserre C.,et al.Cancer Res. 52:5089-5095(1992).
Dusetti N.J.,et al.Genomics 19:108-114(1994).
Lasserre C.,et al.Eur. J. Biochem. 224:29-38(1994).
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