PIP4K2C Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8TBX8 |
Other Accession | O88370, Q91XU3, Q0P5F7 |
Reactivity | Mouse, Rat |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47300 Da |
Gene ID | 79837 |
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Other Names | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma, PIP4K2C, PIP5K2C |
Target/Specificity | This PIP4K2C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 23-57amino acids from the N-terminal region of human PIP4K2C. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PIP4K2C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PIP4K2C (HGNC:23786) |
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Synonyms | PIP5K2C |
Function | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin- dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). |
Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:O88370}. Cytoplasm {ECO:0000250|UniProtKB:O88370} |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum (By similarity).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Daub H.,et al.Mol. Cell 31:438-448(2008).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
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