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FBXL17 Isoform 2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - FBXL17 Isoform 2 Antibody (C-term) AP20590c
    Western blot analysis of lysate from MCF-7 cell line, using FBXL17 Isoform 2 Antibody (C-term) (Cat. #AP20590c). AP20590c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
    detail
  • IHC-P - FBXL17 Isoform 2 Antibody (C-term) AP20590c
    Immunohistochemical analysis of paraffin-embedded H. kidney section using FBXL17 Isoform 2 Antibody (C-term)(Cat#AP20590c). AP20590c was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
    detail
  • IHC-P - FBXL17 Isoform 2 Antibody (C-term) AP20590c
    Immunohistochemical analysis of paraffin-embedded R. kidney section using FBXL17 Isoform 2 Antibody (C-term)(Cat#AP20590c). AP20590c was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
    detail
  • IHC-P - FBXL17 Isoform 2 Antibody (C-term) AP20590c
    Immunohistochemical analysis of paraffin-embedded M. kidney section using FBXL17 Isoform 2 Antibody (C-term)(Cat#AP20590c). AP20590c was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
    detail
  • FC - FBXL17 Isoform 2 Antibody (C-term) AP20590c
    Flow cytometric analysis of MCF-7 cells using FBXL17 Isoform 2 Antibody (C-term)(green, Cat#AP20590c) compared to an isotype control of rabbit IgG(blue). AP20590c was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, FC, WB, E
Primary Accession Q9UF56
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 75695 Da
Additional Information
Gene ID 64839
Other Names F-box/LRR-repeat protein 17, F-box and leucine-rich repeat protein 17, F-box only protein 13, FBXL17, FBL17, FBX13, FBXO13
Target/Specificity This FBXL17 Isoform 2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 262-297 amino acids from the C-terminal region of human FBXL17 Isoform 2.
Dilution WB~~1:1000
IHC-P~~1:25
FC~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXL17 Isoform 2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXL17 {ECO:0000303|PubMed:24035498, ECO:0000312|HGNC:HGNC:13615}
Function Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).
Cellular Location Cytoplasm. Nucleus Note=Present in the cytoplasm and nucleus; more abundant in the cytoplasm.
Research Areas
Citations (0)
citation

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Background

Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 365.00
$ 140.00
Cat# AP20590c
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