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ASB9 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96DX5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31858 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 140462 |
|---|---|
| Other Names | Ankyrin repeat and SOCS box protein 9, ASB-9, ASB9 |
| Target/Specificity | This ASB9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ASB9. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASB9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASB9 {ECO:0000303|PubMed:20302626, ECO:0000312|HGNC:HGNC:17184} |
|---|---|
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:25654263, PubMed:33268465). The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A (PubMed:20302626, PubMed:22418839, PubMed:25654263, PubMed:33268465). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Predominantly expressed in testis, kidney, and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
References
Fei X., et al. Protein J. 31:275-284(2012).
Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kwon S., et al. BMC Biol. 8:23-23(2010).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Bechtel S., et al. BMC Genomics 8:399-399(2007).
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