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SDHA Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - SDHA Antibody (C-term) AP20458b
    SDHA Antibody (C-term) (Cat. #AP20458b) western blot analysis in Hela and mouse C2C12 cell line lysates (35ug/lane).This demonstrates the DHSA antibody detected the DHSA protein (arrow).
    detail
  • IHC-P - SDHA Antibody (C-term) AP20458b
    Immunohistochemical analysis of paraffin-embedded H. skeletal muscle section using SDHA Antibody (C-term)(Cat#AP20458B). AP20458B was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession P31040
Other Accession Q920L2, Q6PA58
Reactivity Human
Predicted Xenopus, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 72692 Da
Antigen Region 577-605 aa
Additional Information
Gene ID 6389
Other Names Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Flavoprotein subunit of complex II, Fp, SDHA, SDH2, SDHF
Target/Specificity This SDHA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 577-605 amino acids from the C-terminal region of human SDHA.
Dilution WB~~1:1000
IHC-P~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSDHA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SDHA
Synonyms SDH2, SDHF
Function Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10746566, PubMed:24781757). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol- oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (PubMed:20484225).
Cellular Location Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Research Areas
Citations (0)
citation

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Background

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.

References

Hirawake H., et al. J. Biochem. 116:221-227(1994).
Morris A.A.M., et al. Biochim. Biophys. Acta 1185:125-128(1994).
Parfait B., et al. Hum. Genet. 106:236-243(2000).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 365.00
$ 140.00
Cat# AP20458b
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