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TSPYL2 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - TSPYL2 Antibody (Center) AP20456c
    TSPYL2 Antibody (Center) (Cat. #AP20456c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the TSPYL2 antibody detected the TSPYL2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H2G4
Other Accession Q9BE64
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 79435 Da
Antigen Region 380-409 aa
Additional Information
Gene ID 64061
Other Names Testis-specific Y-encoded-like protein 2, TSPY-like protein 2, Cell division autoantigen 1, Cutaneous T-cell lymphoma-associated antigen se20-4, CTCL-associated antigen se20-4, Differentially-expressed nucleolar TGF-beta1 target protein, Nuclear protein of 79 kDa, NP79, TSPYL2, CDA1, DENTT, TSPX
Target/Specificity This TSPYL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human TSPYL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTSPYL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSPYL2
Synonyms CDA1, DENTT, TSPX
Function Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Cellular Location Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons
Tissue Location Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas
Research Areas
Citations (0)
citation

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Background

Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

References

Dephoure N., et al. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Chai Z., et al. J. Biol. Chem. 276:33665-33674(2001).
Eichmueller S., et al. Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
Bechtel S., et al. BMC Genomics 8:399-399(2007).
Ross M.T., et al. Nature 434:325-337(2005).

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$ 365.00
$ 140.00
Cat# AP20456c
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