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MORC3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q14149 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 107113 Da |
| Antigen Region | 634-663 aa |
| Gene ID | 23515 |
|---|---|
| Other Names | MORC family CW-type zinc finger protein 3, Zinc finger CW-type coiled-coil domain protein 3, MORC3, KIAA0136, ZCWCC3 |
| Target/Specificity | This MORC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 634-663 amino acids from the Central region of human MORC3. |
| Dilution | WB~~1:1000 IHC-P~~1:100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MORC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MORC3 (HGNC:23572) |
|---|---|
| Function | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN- repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non- methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). |
| Cellular Location | Nucleus, nucleoplasm. Nucleus matrix Nucleus, PML body. Chromosome {ECO:0000250|UniProtKB:F7BJB9}. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent |
| Tissue Location | Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled coil domain.
References
Nagase T., et al. DNA Res. 2:167-174(1995).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Hattori M., et al. Nature 405:311-319(2000).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).
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