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ASB11 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WXH4 |
| Other Accession | Q9CQ31, Q3SZE4 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35367 Da |
| Antigen Region | 26-54 aa |
| Gene ID | 140456 |
|---|---|
| Other Names | Ankyrin repeat and SOCS box protein 11, ASB-11, ASB11 |
| Target/Specificity | This ASB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human ASB11. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASB11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASB11 {ECO:0000303|PubMed:24337577, ECO:0000312|HGNC:HGNC:17186} |
|---|---|
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as BIK, DIRAS2 and RPN1 (PubMed:24337577, PubMed:31387940, PubMed:38574733). The ECS(ASB11) complex acts as a regulator of the endoplasmic reticulum unfolded protein response by mediating ubiquitination and degradation of BIK (PubMed:31387940). |
| Cellular Location | Endoplasmic reticulum |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
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