Mouse Txnip Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q8BG60 |
Other Accession | Q5M7W1, NP_001009935.1 |
Reactivity | Mouse |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44363 Da |
Antigen Region | 116-145 aa |
Gene ID | 56338 |
---|---|
Other Names | Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1 |
Target/Specificity | This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip. |
Dilution | WB~~1:2000 IHC-P~~1:100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Txnip Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Txnip |
---|---|
Synonyms | Vdup1 |
Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:10843682). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (PubMed:15930262). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (By similarity). Required for the maturation of natural killer cells (PubMed:15723808). Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). |
Cellular Location | Cytoplasm. |
Tissue Location | Ubiquitously expressed. |
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Background
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
References
Kwon, H.J., et al. Toxicol. Appl. Pharmacol. 248(3):277-284(2010)
Kwon, H.J., et al. J. Immunol. 185(7):3980-3989(2010)
Ren, Y., et al. FEBS Lett. 584(15):3480-3485(2010)
Chutkow, W.A., et al. Diabetes 59(6):1424-1434(2010)
Shao, Y., et al. Immunol. Lett. 129(2):78-84(2010)
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