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POLDIP3 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IF - POLDIP3 Antibody (N-term) AP20109a
    Fluorescent image of Hela cells stained with POLDIP3 Antibody (N-term)(Cat#AP20109a). AP20109a was diluted at 1:25 dilution. An Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).
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  • WB - POLDIP3 Antibody (N-term) AP20109a
    POLDIP3 Antibody (N-term) (Cat. #AP20109a) western blot analysis in Jurkat,mouse C2C12 cell line lysates (35ug/lane).This demonstrates the POLDIP3 Antibody antibody detected the POLDIP3 Antibody protein (arrow).
    detail
  • IHC-P - POLDIP3 Antibody (N-term) AP20109a
    Immunohistochemical analysis of paraffin-embedded H. stomach section using POLDIP3 Antibody (N-term)(Cat#AP20109a). AP20109a was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, WB, E
Primary Accession Q9BY77
Other Accession Q8BG81, NP_115687.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 46089 Da
Antigen Region 93-120 aa
Additional Information
Gene ID 84271
Other Names Polymerase delta-interacting protein 3, 46 kDa DNA polymerase delta interaction protein, p46, S6K1 Aly/REF-like target, SKAR, POLDIP3, KIAA1649, PDIP46
Target/Specificity This POLDIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of human POLDIP3.
Dilution IF~~1:25
WB~~1:1000
IHC-P~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPOLDIP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name POLDIP3
Synonyms KIAA1649, PDIP46
Function Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.
Cellular Location Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein
Research Areas
Citations (0)
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Background

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified. [provided by RefSeq].

References

Ma, X.M., et al. Cell 133(2):303-313(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Smyk, A., et al. FEBS J. 273(20):4728-4741(2006)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Richardson, C.J., et al. Curr. Biol. 14(17):1540-1549(2004)

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$ 365.00
$ 140.00
Cat# AP20109a
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