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BMPR1B Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O00238 |
| Other Accession | P36898, Q05438, NP_001194 |
| Reactivity | Human |
| Predicted | Chicken, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56930 Da |
| Antigen Region | 472-502 aa |
| Gene ID | 658 |
|---|---|
| Other Names | Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, CDw293, BMPR1B |
| Target/Specificity | This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-502 amino acids from the C-terminal region of human BMPR1B. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BMPR1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BMPR1B |
|---|---|
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Provided below are standard protocols that you may find useful for product applications.
Background
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
References
Kan, L. et al. Stem Cells.January; 27(1): 150?56( 2009).
Lehmann, K., et al., Proc. Natl. Acad. Sci. U.S.A. 100(21):12277-12282 (2003).
Astrom, A.K., et al., Mamm. Genome 10(3):299-302 (1999).
Ide, H., et al., Oncogene 14(11):1377-1382 (1997).
ten Dijke, P., et al., Science 264(5155):101-104 (1994).
Ide, H., et al., Cytogenet. Cell Genet. 81 (3-4), 285-286 (1998).
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