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ZMPSTE24 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75844 |
| Other Accession | Q80W54, NP_005848.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54813 Da |
| Antigen Region | 404-433 aa |
| Gene ID | 10269 |
|---|---|
| Other Names | CAAX prenyl protease 1 homolog, Farnesylated proteins-converting enzyme 1, FACE-1, Prenyl protein-specific endoprotease 1, Zinc metalloproteinase Ste24 homolog, ZMPSTE24, FACE1, STE24 |
| Target/Specificity | This ZMPSTE24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-433 amino acids from the C-terminal region of human ZMPSTE24. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZMPSTE24 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZMPSTE24 {ECO:0000303|PubMed:28246125, ECO:0000312|HGNC:HGNC:12877} |
|---|---|
| Function | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33293369, PubMed:33315887). Proteolytically removes the C- terminal three residues of farnesylated proteins (PubMed:33293369, PubMed:33315887). Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28169297, PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. High levels in kidney, prostate, testis and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Miner, J.H. Am. J. Med. Genet. A 152A (8), 2140-2141 (2010) :
Smigiel, R., et al. Am. J. Med. Genet. A 152A (2), 447-452 (2010) :
Fontaine-Bisson, B., et al. J. Mol. Med. 88(2):193-201(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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