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NFE2L3 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y4A8 |
| Other Accession | NP_004280.5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76154 Da |
| Antigen Region | 666-694 aa |
| Gene ID | 9603 |
|---|---|
| Other Names | Nuclear factor erythroid 2-related factor 3, NF-E2-related factor 3, NFE2-related factor 3, Nuclear factor, erythroid derived 2, like 3, NFE2L3, NRF3 |
| Target/Specificity | This NFE2L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-694 amino acids from the C-terminal region of human NFE2L3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NFE2L3 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NFE2L3 |
|---|---|
| Synonyms | NRF3 |
| Function | Activates erythroid-specific, globin gene expression. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. |
| Tissue Location | Highly expressed in human placenta and also in B- cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Zhang, Y., et al. J. Biol. Chem. 284(5):3195-3210(2009)
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