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STARD13 Antibody(Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - STARD13 Antibody(Center) AP19692c
    STARD13 Antibody (Center) (Cat. #AP19692c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the STARD13 antibody detected the STARD13 protein (arrow).
    detail
  • SPECIFICATION
  • CITATIONS: 7
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y3M8
Other Accession NP_443083.1, NP_821074.1, NP_821075.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 124967 Da
Antigen Region 544-573 aa
Additional Information
Gene ID 90627
Other Names StAR-related lipid transfer protein 13, 46H232, Deleted in liver cancer 2 protein, DLC-2, Rho GTPase-activating protein, START domain-containing protein 13, StARD13, STARD13, DLC2, GT650
Target/Specificity This STARD13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 544-573 amino acids from the Central region of human STARD13.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTARD13 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STARD13
Synonyms DLC2, GT650
Function GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet
Tissue Location Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines
Research Areas
Citations ( 0 )

Background

This gene encodes a protein that contains a sterile alpha motif domain in the N-terminus, an ATP/GTP-binding motif, a GTPase-activating protein domain, and a STAR-related lipid transfer domain in the C-terminus. The gene is located in a region of chromosome 13 that has loss of heterozygosity in hepatic cancer. At least three alternatively spliced transcript variants have been described for this gene.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Xiaorong, L., et al. BMC Cancer 8, 205 (2008) :

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$ 182.50
$ 70.00
Cat# AP19692c
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