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TCF7 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P36402 |
| Other Accession | Q00417, Q86WR9 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41642 Da |
| Antigen Region | 3-36 aa |
| Gene ID | 6932 |
|---|---|
| Other Names | Transcription factor 7, TCF-7, T-cell-specific transcription factor 1, T-cell factor 1, TCF-1, TCF7, TCF1 |
| Target/Specificity | This TCF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-36 amino acids from the N-terminal region of human TCF7. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TCF7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TCF7 |
|---|---|
| Synonyms | TCF1 |
| Function | Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T- cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. |
| Cellular Location | Nucleus. |
| Tissue Location | Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium |
Provided below are standard protocols that you may find useful for product applications.
Background
The T cell specific transcription factor TCF7 activates genes involved in immune regulation and thymocyte differentiation, and is a candidate locus for genetic susceptibility to type 1 diabetes.
References
Smit, L., et al., J. Biol. Chem. 279(17):17232-17240 (2004).
Ioannidis, V., et al., J. Immunol. 171(2):769-775 (2003).
Noble, J.A., et al., Diabetes 52(6):1579-1582 (2003).
Batlle, E., et al., Cell 111(2):251-263 (2002).
van de Wetering, M., et al., J. Biol. Chem. 267(12):8530-8536 (1992).
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