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MYBBP1A Antibody(N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MYBBP1A Antibody(N-term) AP19507A
    MYBBP1A Antibody (N-term) (Cat. #AP19507a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the MYBBP1A antibody detected the MYBBP1A protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BQG0
Other Accession NP_055335.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 148855 Da
Antigen Region 258-287 aa
Additional Information
Gene ID 10514
Other Names Myb-binding protein 1A, MYBBP1A, P160
Target/Specificity This MYBBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from the N-terminal region of human MYBBP1A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYBBP1A Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYBBP1A
Synonyms P160
Function May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).
Cellular Location Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4}
Research Areas
Citations (0)
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Background

MYBBP1A may activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity).

References

Perrera, C., et al. J. Biol. Chem. 285(16):11775-11785(2010)
Fuller, H.R., et al. J. Proteome Res. 9(1):556-563(2010)
Redmond, A.M., et al. Clin. Cancer Res. 15(6):2098-2106(2009)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Al-azawi, D., et al. Oncogene 27(21):3021-3031(2008)

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$ 182.50
$ 70.00
Cat# AP19507A
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