MYBBP1A Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BQG0 |
Other Accession | NP_055335.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 148855 Da |
Antigen Region | 258-287 aa |
Gene ID | 10514 |
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Other Names | Myb-binding protein 1A, MYBBP1A, P160 |
Target/Specificity | This MYBBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from the N-terminal region of human MYBBP1A. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MYBBP1A Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MYBBP1A |
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Synonyms | P160 |
Function | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). |
Cellular Location | Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
MYBBP1A may activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity).
References
Perrera, C., et al. J. Biol. Chem. 285(16):11775-11785(2010)
Fuller, H.R., et al. J. Proteome Res. 9(1):556-563(2010)
Redmond, A.M., et al. Clin. Cancer Res. 15(6):2098-2106(2009)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Al-azawi, D., et al. Oncogene 27(21):3021-3031(2008)
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