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RCL1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y2P8 |
| Other Accession | Q2KHX8 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40843 Da |
| Antigen Region | 14-43 aa |
| Gene ID | 10171 |
|---|---|
| Other Names | RNA 3'-terminal phosphate cyclase-like protein, RCL1, RNAC, RPC2, RPCL1, RTC2 |
| Target/Specificity | This RCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human RCL1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RCL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RCL1 (HGNC:17687) |
|---|---|
| Synonyms | RNAC, RPC2, RPCL1, RTC2 |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (PubMed:34516797). Does not have cyclase activity (By similarity). |
| Cellular Location | Nucleus, nucleolus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RCL1, which does not have cyclase activity, plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
References
Billy, E., et al., EMBO J. 19(9):2115-2126 (2000).
Genschik P., et al., EMBO J. 16(10):2955-67 (1997).
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