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TRIM29 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - TRIM29 Antibody (Center) AP19332c
    TRIM29 Antibody (Center) (Cat. #AP19332c) western blot analysis in SW480 cell line lysates (35ug/lane).This demonstrates the TRIM29 antibody detected the TRIM29 protein (arrow).
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  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14134
Other Accession Q8R2Q0, NP_036233.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 65835 Da
Antigen Region 336-365 aa
Additional Information
Gene ID 23650
Other Names Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC
Target/Specificity This TRIM29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human TRIM29.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM29 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM29
Synonyms ATDC
Function Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Cellular Location Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments
Tissue Location Expressed in placenta, prostate and thymus.
Research Areas
Citations ( 0 )

Background

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yuan, Z., et al. Mol. Cell. Biol. 30(12):3004-3015(2010)
Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)
Bertrand-Vallery, V., et al. PLoS ONE 5 (5), E10462 (2010) :
Ring, B.Z., et al. Mod. Pathol. 22(8):1032-1043(2009)

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$ 365.00
$ 140.00
Cat# AP19332c
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