HMOX2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P30519 |
Other Accession | P23711, O70252, Q2PG53, NP_002125.3 |
Reactivity | Human |
Predicted | Monkey, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 36033 Da |
Antigen Region | 24-52 aa |
Gene ID | 3163 |
---|---|
Other Names | Heme oxygenase 2, HO-2, HMOX2, HO2 |
Target/Specificity | This HMOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human HMOX2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HMOX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HMOX2 |
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Synonyms | HO2 |
Function | [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. |
Cellular Location | Microsome membrane; Single-pass type IV membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:P09601} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus.
References
Abdel Aziz, M.T., et al. Andrologia 42(4):236-241(2010)
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
He, J.Z., et al. J. Biol. Chem. 285(13):9452-9461(2010)
Zhong, J.L., et al. Free Radic. Biol. Med. 48(2):196-206(2010)
Yun, L., et al. Clin. Exp. Hypertens. 31(7):534-543(2009)
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