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NUP54 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z3B4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55435 Da |
| Antigen Region | 211-243 aa |
| Gene ID | 53371 |
|---|---|
| Other Names | Nucleoporin p54, 54 kDa nucleoporin, NUP54 |
| Target/Specificity | This NUP54 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-243 amino acids from the Central region of human NUP54. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NUP54 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NUP54 |
|---|---|
| Function | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. |
| Cellular Location | Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P70582}. Nucleus membrane {ECO:0000250|UniProtKB:P70582}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70582}; Cytoplasmic side {ECO:0000250|UniProtKB:P70582}. Nucleus membrane {ECO:0000250|UniProtKB:P70582}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70582}; Nucleoplasmic side {ECO:0000250|UniProtKB:P70582}. Note=Biased towards cytoplasmic side Central region of the nuclear pore complex, within the transporter {ECO:0000250|UniProtKB:P70582} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. NUP54 is a member of the phe-gly (FG) repeat-containing nucleoporin subset.
References
Stoffler, D., et al., Curr. Opin. Cell Biol. 11(3):391-401 (1999).
Bodoor, K., et al., Biochem. Cell Biol. 77(4):321-329 (1999).
Popov, S., et al., J. Biol. Chem. 273(21):13347-13352 (1998).
Hu, T., et al., J. Cell Biol. 134(3):589-601 (1996).
Finlay, D.R., et al., J. Cell Biol. 114(1):169-183 (1991).
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