Mouse Stk38 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q91VJ4 |
Other Accession | Q15208, A2VDV2, NP_598876.1 |
Reactivity | Mouse |
Predicted | Bovine, Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54174 Da |
Antigen Region | 429-458 aa |
Gene ID | 106504 |
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Other Names | Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, Stk38 {ECO:0000312|EMBL:AAH096581} |
Target/Specificity | This Mouse Stk38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-458 amino acids from the C-terminal region of mouse Stk38. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Stk38 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Stk38 {ECO:0000312|EMBL:AAH09658.1} |
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Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:21730291). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q15208}. Cytoplasm {ECO:0000250|UniProtKB:Q15208}. Chromosome {ECO:0000250|UniProtKB:Q15208}. Note=Localizes to DNA double-strand breaks in response to DNA damage. {ECO:0000250|UniProtKB:Q15208} |
Tissue Location | Expressed at high levels in spleen, lung, thymus, brain and fat tissue. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
References
Cornils, H., et al. Sci Signal 3 (126), RA47 (2010) :
Stegert, M.R., et al. J. Biol. Chem. 279(22):23806-23812(2004)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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