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GNB4 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - GNB4 Antibody (Center) AP19123c
    GNB4 Antibody (Center) (Cat. #AP19123c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the GNB4 antibody detected the GNB4 protein (arrow).
    detail
  • WB - GNB4 Antibody (Center) AP19123c
    Anti-GNB4 Antibody (Center) at 1:1000 dilution + human lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 38 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9HAV0
Other Accession O35353, P29387, P79959, P54311, P62874, P62873, P26308, Q6PH57, Q6TMK6, P62871, NP_067642.1
Reactivity Human
Predicted Bovine, Hamster, Zebrafish, Drosophila, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 37567 Da
Antigen Region 109-138 aa
Additional Information
Gene ID 59345
Other Names Guanine nucleotide-binding protein subunit beta-4, Transducin beta chain 4, GNB4
Target/Specificity This GNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human GNB4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGNB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNB4
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Tissue Location Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves
Research Areas
Citations (0)
citation

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Background

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

References

Riemann, K., et al. Anticancer Res. 29(4):1271-1274(2009)
Riemann, K., et al. Pharmacogenet. Genomics 18(11):999-1008(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Rosskopf, D., et al. FEBS Lett. 544 (1-3), 27-32 (2003) :
Jiang, G., et al. Am. J. Physiol. Endocrinol. Metab. 284 (4), E671-E678 (2003) :

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$ 365.00
$ 140.00
Cat# AP19123c
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