PES1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O00541 |
Other Accession | NP_055118.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 68003 Da |
Antigen Region | 549-578 aa |
Gene ID | 23481 |
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Other Names | Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028}, PES1 {ECO:0000255|HAMAP-Rule:MF_03028} |
Target/Specificity | This PES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-578 amino acids from the C-terminal region of human PES1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PES1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PES1 {ECO:0000255|HAMAP-Rule:MF_03028} |
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Function | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP- Rule:MF_03028} |
Tissue Location | Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.
References
Zhang, J., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(12):991-997(2009)
Li, J., et al. Cancer Sci. 100(12):2255-2260(2009)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Rohrmoser, M., et al. Mol. Cell. Biol. 27(10):3682-3694(2007)
Grimm, T., et al. Nucleic Acids Res. 34(10):3030-3043(2006)
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